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[维拉帕米在不同心肌缺血模型中抗缺血作用的比较评价]

[A comparative evaluation of the anti-ischemic action of verapamil in different models of myocardial ischemia].

作者信息

Gurbanov K K, Kovalev G V, Paperno A A

出版信息

Farmakol Toksikol. 1991 Jul-Aug;54(4):21-3.

PMID:1786814
Abstract

The effectiveness of the anti-ischemic effect of verapamil was studied on models of coronary spasm (the test with dihydroergotamine) and microthrombosis of the coronary arteries (the test with ADP). The results of the performed studies showed that verapamil exerts the anti-ischemic effect at administration of dihydroergotamine and ADP. The most pronounced effect of verapamil was demonstrated on the model of myocardial ischemia due to coronary spasm.

摘要

在冠状动脉痉挛模型(双氢麦角胺试验)和冠状动脉微血栓形成模型(ADP试验)上研究了维拉帕米的抗缺血作用效果。所进行的研究结果表明,在给予双氢麦角胺和ADP时维拉帕米发挥抗缺血作用。维拉帕米在冠状动脉痉挛所致心肌缺血模型上表现出最显著的效果。

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