Gurbanov K G, Paperno A A, Luk'ianenko N G, Basok S S
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):18-21.
Experiments on open-chest anaesthetized cats were made to test derivatives of crown ethers, such as benzylase-15-crown-5 and dibenzylase-15-crown-5 for their effects on myocardial ischemia and the functional status of a myocardial ischemic focus in temporary coronary occlusion during coronary spasm induced by dihydroergotamine and during coronary microthrombosis caused by ADP. When intravenously administered in doses of 0.5-15 mg/kg, the tested agents were found to enhance myocardial tolerance to ischemia, depressed ST segment in ischemia induced by coronary occlusion and administration of ATP, and prevented ST-segment depression during coronary spasm.
在开胸麻醉猫身上进行实验，以测试冠醚衍生物，如苄基化-15-冠-5和二苄基化-15-冠-5，在双氢麦角胺诱发的冠状动脉痉挛以及ADP引起的冠状动脉微血栓形成期间，对心肌缺血和冠状动脉暂时闭塞时心肌缺血灶功能状态的影响。当以0.5-15mg/kg的剂量静脉给药时，发现受试药物可增强心肌对缺血的耐受性，降低冠状动脉闭塞和给予ATP诱导的缺血中的ST段，并预防冠状动脉痉挛期间的ST段压低。
