Madhavan Nandita, Gin Mary S
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.
Chembiochem. 2007 Oct 15;8(15):1834-40. doi: 10.1002/cbic.200700321.
Ion-channel mimics are able to transmit electrical signals across phospholipid membranes, and can be envisioned as nanoswitches for molecular electronics. Here, we reported the use of pH to alter ion-transport rates through a synthetic aminocyclodextrin ion channel. Both cation- and anion-transport rates were found to increase with an increase in pH due to the unique electrostatics of the multiple ammonium groups that line the channel pore. Such pH regulation of ion transport rates is unique and can be exploited for sensing applications.
离子通道模拟物能够跨磷脂膜传输电信号，可被设想为分子电子学中的纳米开关。在此，我们报道了利用pH值来改变通过合成氨基环糊精离子通道的离子传输速率。由于通道孔内排列的多个铵基团具有独特的静电作用，阳离子和阴离子的传输速率均随pH值的升高而增加。这种对离子传输速率的pH调节是独特的，可用于传感应用。
