Piianzin A I, Popova N K, Markel' A L
Farmakol Toksikol. 1991 Jul-Aug;54(4):28-30.
The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.
研究了高亲和力C1A血清素受体激动剂氟西诺生对正常血压的Wistar大鼠、自发性高血压大鼠和遗传性应激诱导性动脉高血压大鼠的动脉血压和心率的影响。结果表明，外周和中枢给予氟西诺生均可降低血压和心率。然而，药物外周给药时心率降低更为明显。高血压大鼠对氟西诺生的敏感性高于正常血压大鼠。
