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[血清素受体（S2）的药理学阻断对两种遗传性动脉高血压大鼠动脉血压的影响]

[The effect of pharmacologic blockade of serotonin receptors (S2) on arterial pressure in rats with 2 forms of hereditary arterial hypertension].

作者信息

Popova N K, Piianzin A I, Markel' A L

出版信息

Farmakol Toksikol. 1989 Nov-Dec;52(6):58-61.

PMID:2516487
Abstract

The influence of blockade of serotonin S2 receptors with ketanserin was studied in two strains of rats with inherited arterial hypertension: spontaneously hypertensive rats (SHR strain) and rats with inherited stress-induced arterial hypertension (ISIAH strain). It was found that peripheral injection of ketanserin produced a greater decrease of arterial blood pressure than i.c.v. administration. ISIAH rats were more sensitive to the hypotensive effect of ketanserin when compared to normotensive Wistar or SHR rats.

摘要

在两种遗传性动脉高血压大鼠品系中研究了酮色林阻断5-羟色胺S2受体的影响：自发性高血压大鼠（SHR品系）和遗传性应激诱导性动脉高血压大鼠（ISIAH品系）。发现外周注射酮色林比脑室内给药能使动脉血压有更大程度的降低。与正常血压的Wistar大鼠或SHR大鼠相比，ISIAH大鼠对酮色林的降压作用更敏感。

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1
[The effect of pharmacologic blockade of serotonin receptors (S2) on arterial pressure in rats with 2 forms of hereditary arterial hypertension].[血清素受体（S2）的药理学阻断对两种遗传性动脉高血压大鼠动脉血压的影响]
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