疑似胰高血糖素瘤患者血浆胰高血糖素免疫反应性的分布

Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma.

作者信息

Valverde I, Lemon H M, Kessinger A, Unger R H

出版信息

J Clin Endocrinol Metab. 1976 May;42(5):804-8. doi: 10.1210/jcem-42-5-804.

Abstract

Gel filtration of plasma from a patient with a clinical syndrome of glucagonoma and a total plasma glucagon level of 2600 pg/ml, revealed the four glucagon immunoreactive fractions found in normal subjects. The total hyperglucagonemia observed was due to high levels of true glucagon and proglucagon moieties. The so-called "big plasma glucagon" (BPG) measured 190 pg/ml (normal average 113 +/- 79 pg/ml, Mean +/- SD, N = 10); the large glucagon immunoreactivity, LGI (9000 mol wt), measured 625 pg/ml (normal average 11 +/- 16 pg/ml); the true glucagon accounted for 1435 pg/ml (normal average 31 +/- 29 pg/ml); and the small glucagon immunoreactive fraction (approximately 2000 mol wt) measured 35 pg/ml (normal average 26 +/- 18 pg/ml). The high levels of LGI, considered a candidate for proglucagon, may reflect the increased secretory activity of the tumor.

摘要

对一名患有胰高血糖素瘤临床综合征且血浆胰高血糖素总水平为2600 pg/ml的患者的血浆进行凝胶过滤，发现了正常受试者体内存在的四种胰高血糖素免疫反应性组分。观察到的总高胰高血糖素血症是由于真实胰高血糖素和胰高血糖素原部分的高水平所致。所谓的“大血浆胰高血糖素”（BPG）为190 pg/ml（正常平均值为113±79 pg/ml，均值±标准差，N = 10）；大胰高血糖素免疫反应性物质，LGI（9000分子量）为625 pg/ml（正常平均值为11±16 pg/ml）；真实胰高血糖素占1435 pg/ml（正常平均值为31±29 pg/ml）；小胰高血糖素免疫反应性组分（约2000分子量）为35 pg/ml（正常平均值为26±18 pg/ml）。被认为是胰高血糖素原候选物的LGI的高水平可能反映了肿瘤分泌活性的增加。