Palmer J P, Werner P L, Benson J W, Ensinck J W
J Clin Invest. 1978 Mar;61(3):763-9. doi: 10.1172/JCI108990.
Plasma from some individuals contains substances which are reactive with glucagon antiserum, are larger than 3,500-dalton glucagon, and have been proposed as possible precursors of glucagon. We have evaluated three generations of a kindred in which 9 of 15 members evaluated had elevated plasma levels of large molecular weight immunoreactive glucagon (L-IRG) with an average concentration of 822 pg/ml. The distribution of individuals with elevated L-IRG levels in this pedigree is consistent with autosomal dominant inheritance. Gel filtration of plasma revealed that all affected family members had excessive amounts of two L-IRG peaks, one with a molecular weight of approximately 9,000 daltons and another in the 10,000 to 20,000-dalton range. Oral glucose tolerance tests were nondiabetic and elicited a fall in L-IRG levels, whereas L-IRG concentrations rose dramatically during the infusion of arginine. These L-IRG species may be precursors of 3,500-DALTON GLUCAGON AND MAY BE ELEVATED in this kindred because of an inherited defect in either their synthesis or degradation.
一些人的血浆中含有与胰高血糖素抗血清发生反应的物质，这些物质比3500道尔顿的胰高血糖素大，并且被认为可能是胰高血糖素的前体。我们评估了一个家族的三代成员，在接受评估的15名成员中，有9人的血浆中大分子免疫反应性胰高血糖素（L-IRG）水平升高，平均浓度为822 pg/ml。该家族中L-IRG水平升高的个体分布符合常染色体显性遗传。血浆的凝胶过滤显示，所有受影响的家庭成员都有过量的两个L-IRG峰，一个分子量约为9000道尔顿，另一个在10000至20000道尔顿范围内。口服葡萄糖耐量试验结果为非糖尿病，且L-IRG水平下降，而在输注精氨酸期间，L-IRG浓度急剧上升。这些L-IRG物质可能是3500道尔顿胰高血糖素的前体，并且在这个家族中可能由于其合成或降解的遗传缺陷而升高。
