Lin Xiao-Ming, Tian Wei, Ma Le, Long Zhu, Zhang Juan, Shen Xiao-Yi, Zhang Xiao-Peng
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100083, China.
Br J Nutr. 2008 Feb;99(2):416-20. doi: 10.1017/S0007114507797040. Epub 2007 Sep 10.
We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (IDE) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were divided into four groups: normal, Fe store depletion, IDE and IDA. A total of 131 women were randomly selected from the normal, IDE and IDA groups. Subsequently, seventy-six women with IDE and IDA were given various doses of Fe (14 mg/d for IDE; 28 mg/d for IDA) with ferrous l-threonate capsules for twelve consecutive weeks. After receiving Fe supplements, the levels of Fe and sTfR were determined at weeks 0, 3, 6, 9 and 12. The levels of sTfR in women of childbearing age with IDE and IDA were significantly higher than those in the normal group. After receiving Fe supplements, the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased. In conclusion, STfR can be used as a reliable indicator for assessing the efficacy of Fe supplements.
我们旨在研究血清转铁蛋白受体（sTfR）对缺铁性红细胞生成（IDE）和缺铁性贫血（IDA）的育龄妇女补充铁剂的反应。对942名年龄在18至45岁之间的女性进行了初步筛查。在测定血清铁蛋白、锌原卟啉和血红蛋白等与铁相关的生化指标后，将受试者分为四组：正常组、铁储存耗竭组、IDE组和IDA组。从正常组、IDE组和IDA组中随机选取了131名女性。随后，76名患有IDE和IDA的女性连续12周每日服用不同剂量的铁（IDE组为14毫克/天；IDA组为28毫克/天），通过l-苏糖酸亚铁胶囊给药。补充铁剂后，在第0、3、6、9和12周测定铁和sTfR的水平。患有IDE和IDA的育龄妇女的sTfR水平显著高于正常组。补充铁剂后，患有IDE和IDA的育龄妇女的sTfR水平显著降低，而血清铁蛋白水平显著升高。总之，sTfR可作为评估铁剂补充疗效的可靠指标。
