Naito Mariko, Nakayama Takeo, Okamura Tomonori, Miura Katsuyuki, Yanagita Masahiko, Fujieda Yoshiharu, Kinoshita Fujihisa, Naito Yoshihiko, Nakagawa Hideaki, Tanaka Taichiro, Ueshima Hirotsugu
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Atherosclerosis. 2008 Apr;197(2):784-90. doi: 10.1016/j.atherosclerosis.2007.07.026. Epub 2007 Sep 14.
Individuals who are physically fit or engage in regular physical activity have a lower incidence of cardiovascular disease and risk of mortality. We conducted a large-scale controlled trial of interventions to decrease cardiovascular risk factors, during which we assessed the effect of a workplace-based intervention program, which was part of a population strategy for promoting long-term increases in physical activity, on the blood lipid profiles of participating employees. Data were collected from 2929 participants and this report presents the results of a survey conducted in five factories for the intervention group and five factories for the control group at baseline and year 5. The absolute/proportional changes in HDL-cholesterol were 2.7 mg/dL (4.8%) in the intervention group and -0.6 mg/dL (-1.0%) in the control group. The differences between the two groups in the change in serum levels of HDL-cholesterol were highly significant (p<0.001) in each analysis of covariance, in which the number of cigarettes smoked was included or excluded. In the intervention group, the daily walking time increased significantly (p<0.001) when compared between baseline and year 5, whereas no significant difference was observed in daily walking time in the control group over the identical period. Our results show that an intervention program promoting physical activity raises serum HDL-cholesterol levels of middle-aged employees. Increased awareness of the benefits of physical activity, using environmental rearrangement and health promotion campaigns, which especially target walking, may have contributed to a beneficial change in serum HDL-cholesterol levels in the participants.
身体健康或经常进行体育活动的人患心血管疾病的几率和死亡风险较低。我们进行了一项大规模的干预对照试验以降低心血管危险因素，在此期间，我们评估了一项基于工作场所的干预计划对参与员工血脂谱的影响，该计划是促进体育活动长期增加的人群策略的一部分。从2929名参与者中收集了数据，本报告展示了在基线期和第5年时，对干预组的五家工厂和对照组的五家工厂进行调查的结果。干预组高密度脂蛋白胆固醇的绝对/比例变化为2.7毫克/分升（4.8%），对照组为-0.6毫克/分升（-1.0%）。在包含或排除吸烟数量的各协方差分析中，两组高密度脂蛋白胆固醇血清水平变化的差异均具有高度显著性（p<0.001）。在干预组中，与基线期相比，第5年时每日步行时间显著增加（p<0.001），而在同一时期对照组的每日步行时间未观察到显著差异。我们的结果表明，一项促进体育活动的干预计划提高了中年员工的血清高密度脂蛋白胆固醇水平。利用环境改造和健康促进活动，特别是以步行作为目标，提高对体育活动益处的认识，可能有助于参与者血清高密度脂蛋白胆固醇水平发生有益变化。
