Bain Barbara J, Fletcher Sarah H
Department of Haematology, St Mary's Hospital Campus of Imperial College Faculty of Medicine, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Immunol Allergy Clin North Am. 2007 Aug;27(3):377-88. doi: 10.1016/j.iac.2007.06.001.
Among patients with hypereosinophilia, a myeloproliferative variant is recognized. In many of these patients a diagnosis of eosinophilic leukemia can be made. The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated.
在嗜酸性粒细胞增多症患者中，可识别出一种骨髓增殖性变体。在许多这类患者中，可以作出嗜酸性粒细胞白血病的诊断。分子机制通常是一种融合基因，它包含部分血小板衍生生长因子受体A（PDGFRA）或血小板衍生生长因子受体B（PDGFRB），编码一种异常的酪氨酸激酶。由于需要使用特定的酪氨酸激酶抑制剂进行治疗，因此对此类病例进行及时诊断很重要。
