Haydon Steven J, Ross Danielle E, Caucci Stephen, Clark Shane, Hrinczenko Borys
Internal Medicine, Mclaren Greater Lansing, Lansing, USA.
College of Osteopathic Medicine, Michigan State University, East Lansing, USA.
Cureus. 2025 Feb 24;17(2):e79548. doi: 10.7759/cureus.79548. eCollection 2025 Feb.
positive chronic eosinophilic leukemia (CEL) is a rare subtype of myeloproliferative neoplasm characterized by organ damage caused by eosinophilic granules containing cytokines and humoral factors. These include interleukin-5 (IL-5), interleukin-4 (IL-4), and interleukin-13 (IL-13). We present a case study of a 71-year-old male who initially presented with cough, fever, night sweats, and weight loss. Fluorescence in situ hybridization (FISH) and cytogenetic testing confirmed that the patient had positive chronic eosinophilic leukemia. Treatment with imatinib and prednisone led to a rapid decrease in the eosinophil count without further damage from eosinophilic infiltration. Our patient has tolerated therapy with occasional lightheadedness that he attributed to external factors, and he continues to remain in remission. This case study aims to contribute to the existing knowledge regarding the discovery and treatment of this disease.
阳性慢性嗜酸性粒细胞白血病（CEL）是骨髓增殖性肿瘤的一种罕见亚型，其特征是由含有细胞因子和体液因子的嗜酸性粒细胞颗粒引起的器官损伤。这些因子包括白细胞介素-5（IL-5）、白细胞介素-4（IL-4）和白细胞介素-13（IL-13）。我们报告一例71岁男性病例，该患者最初表现为咳嗽、发热、盗汗和体重减轻。荧光原位杂交（FISH）和细胞遗传学检测证实该患者患有阳性慢性嗜酸性粒细胞白血病。伊马替尼和泼尼松治疗导致嗜酸性粒细胞计数迅速下降，且未因嗜酸性粒细胞浸润造成进一步损害。我们的患者耐受了治疗，偶尔出现头晕，他将其归因于外部因素，并且他仍处于缓解状态。本病例研究旨在为有关该疾病的发现和治疗的现有知识做出贡献。
