鼻一氧化氮的测量。

Measurement of nasal nitric oxide.

作者信息

Corbelli Regula, Hammer Jürg

机构信息

University Children's Hospital, Geneva, Switzerland.

出版信息

Paediatr Respir Rev. 2007 Sep;8(3):269-72. doi: 10.1016/j.prrv.2007.07.007. Epub 2007 Sep 6.

DOI:10.1016/j.prrv.2007.07.007

PMID:17868927

Abstract

Nasal nitric oxide (nNO) is produced in high quantity in the upper airways. It is thought to be involved in host defence functions and regulation of mucociliary function, and to serve as a biochemical airborne transmitter. The measurement of nNO is easy and non-invasive. It has evolved as a screening test to exclude primary ciliary dyskinesia (PCD) in patients with suggestive symptoms, because nNO is extremely low in this condition. Nasal NO is also altered in other nasal, sinus and pulmonary pathologies, but is without diagnostic value outside of PCD.

摘要

鼻一氧化氮（nNO）在上呼吸道大量产生。它被认为参与宿主防御功能和黏液纤毛功能的调节，并作为一种生化空气传播递质。nNO的测量简便且无创。它已发展成为一种筛查试验，用于排除有提示性症状患者的原发性纤毛运动障碍（PCD），因为在这种情况下nNO极低。鼻一氧化氮在其他鼻腔、鼻窦和肺部疾病中也会发生改变，但在PCD之外没有诊断价值。