Department of Otorhinolaryngology, Head and Neck Surgery, Centre for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany.
Int Arch Allergy Immunol. 2011;156(4):352-61. doi: 10.1159/000324678. Epub 2011 Aug 9.
Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an important role in host defense, and is liberated in the nose and the paranasal sinuses. This review aims to highlight some aspects of the origin and function of NO in airway diseases, such as allergic rhinitis, chronic rhinosinusitis with and without nasal polyps, primary ciliary dyskinesia, and cystic fibrosis. In conclusion, NO measurement may be a promising noninvasive diagnostic marker for airway pathologies.
一氧化氮（NO）是一种强效的生物调节剂，在广泛的细胞和组织功能中具有调节作用。在上呼吸道和下呼吸道中，NO 被认为参与了具有调节、保护、防御或损害作用的不同功能。显然，NO 在宿主防御中起着重要作用，并在鼻腔和副鼻窦中释放。本综述旨在强调 NO 在气道疾病（如变应性鼻炎、伴有和不伴有鼻息肉的慢性鼻-鼻窦炎、原发性纤毛运动障碍和囊性纤维化）中的起源和功能的某些方面。总之，NO 测量可能是气道病变有前途的非侵入性诊断标志物。
