Roberts William S, Lonsdale Daniel J, Griffiths John, Higson Séamus P J
Cranfield Health, Cranfield University, Barton Road, Silsoe, Bedfordshire MK45 4DT, United Kingdom.
Biosens Bioelectron. 2007 Oct 31;23(3):301-18. doi: 10.1016/j.bios.2007.06.020. Epub 2007 Jul 31.
Scanning electrochemical microscopy (SECM) is a powerful surface characterisation technique that allows for the electrochemical profiling of surfaces with sub micrometer resolution. While SECM has been most widely used to electrochemically study and profile non-biological surfaces and processes, the technique has in recent years, been increasingly used for the study of biological systems - and this is the focus of this review. An overview of SECM and how the technique may be applied to the study of biological systems will first be given. SECM and its application to the study of cells, enzymes and DNA will each be considered in detail. The review will conclude with a discussion of future directions and scope for further developments and applications.
扫描电化学显微镜（SECM）是一种强大的表面表征技术，可实现亚微米分辨率的表面电化学成像分析。虽然SECM已最广泛地用于电化学研究非生物表面和过程，但近年来该技术越来越多地用于生物系统的研究——这也是本综述的重点。本文将首先概述SECM以及该技术如何应用于生物系统的研究。随后将详细探讨SECM及其在细胞、酶和DNA研究中的应用。综述将以对未来发展方向以及进一步开发和应用的范围的讨论作为结尾。
