Hirasawa Yusuke, Izawa Emi, Matsuno Yosuke, Kawahara Nobuo, Goda Yukihiro, Morita Hiroshi
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5868-71. doi: 10.1016/j.bmcl.2007.08.012. Epub 2007 Aug 11.
Two new abietane-type diterpenes, taxodistines A (1) and B (2), have been isolated by the guidance of inhibitory effect of tubulin polymerization from the fruits of Taxodium distichum and the structures were elucidated by using 2D NMR data. Taxodistine B (2) showed inhibition of tubulin polymerization.
通过微管蛋白聚合抑制作用的引导，从落羽杉果实中分离出两种新的枞酸型二萜化合物，即落羽杉素A（1）和落羽杉素B（2），并利用二维核磁共振数据阐明了其结构。落羽杉素B（2）表现出对微管蛋白聚合的抑制作用。
