Distribution of detoxifying genes polymorphism in Maharastrian population of central India.

作者信息

Saravana Devi Sivanesan, Vinayagamoorthy Nadimuthu, Agrawal Meenal, Biswas Arup, Biswas Raka, Naoghare Pravin, Kumbhakar Sreya, Krishnamurthi Kannan, Hengstler Jan G, Hermes Matthias, Chakrabarti Tapan

机构信息

Environmental Biotechnology Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur, Maharashtra 440 020, India.

出版信息

Chemosphere. 2008 Feb;70(10):1835-9. doi: 10.1016/j.chemosphere.2007.08.008. Epub 2007 Sep 14.

DOI:10.1016/j.chemosphere.2007.08.008

PMID:17869325

Abstract

The present study is aimed at evaluating the genotype frequency of detoxifying genes such as GSTM1, GSTT1 and NQO1 in Maharastrian population of central India. The study revealed about 64.6% of GSTM1-positive and 35.4% GSTM1-null population. GSTT1-positive genotype was found to be 87.5% and GSTT1-null showed 12.5%. The NQO1 genotype of Maharastrian population showed 52.3% of C/C, 42.48% C/T and 5.18% T/T. The NQO1 of this population does not deviate from the expected Hardy-Weinberg equilibrium. The genotype frequencies GSTM1 and GSTT1 of the population when compared with other ethnic groups of Asia and Caucasians show distinct nature of Maharastrian population from other Asian and Caucasian population.

摘要