Lee K, Magalhaes I, Clavel C, Briolat J, Birembaut P, Tommasino M, Zehbe I
Regional Cancer Care, Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada.
Virus Res. 2008 Jan;131(1):106-10. doi: 10.1016/j.virusres.2007.08.003. Epub 2007 Sep 14.
The human papillomavirus (HPV) 16 E6 genome variant 350G has been found to be more prevalent in women with persistent infection and cervical disease progression than the HPV16 E6 prototype 350T. In this study, we examined whether women who progressed to a high-grade lesion, yet were infected with the prototype 350T, showed variants in other HPV genes such as L1, L2 and E2. Although we detected variants within these genes, they could not explain this phenomenon. Indeed they correlated similarly with variant 350G and prototype 350T. These data indicate that polymorphisms in HPV16 E6 rather than in the other analyzed genes play a role in determining the risk for cervical lesion progression and that additional factors are likely to be required as well.
已发现人乳头瘤病毒（HPV）16 E6基因组变体350G在持续感染和宫颈疾病进展的女性中比HPV16 E6原型350T更为普遍。在本研究中，我们检测了进展为高级别病变但感染了原型350T的女性，其其他HPV基因（如L1、L2和E2）是否存在变体。虽然我们在这些基因中检测到了变体，但它们无法解释这一现象。实际上，它们与变体350G和原型350T的相关性相似。这些数据表明，HPV16 E6而非其他分析基因中的多态性在决定宫颈病变进展风险中起作用，并且可能还需要其他因素。
