Biruss Babette, Valenta Claudia
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
Int J Pharm. 2008 Feb 12;349(1-2):269-73. doi: 10.1016/j.ijpharm.2007.08.003. Epub 2007 Aug 11.
The influence of progesterone on the physicochemical behaviour of the o/w microemulsion consisting of the non-ionic surfactant polyoxyethylene-10-dodecyl ether, tributyrin and water was investigated. Thereby no significant influence could be detected in terms of droplet size, zeta potential, conductivity and pH by progesterone. However the chemical stability of progesterone was insufficient during the storage of 6 months. Therefore, two different polymeric agents, named silicon dioxide and polymeric emulsifier, were added to the progesterone containing microemulsions. These polymers increased the chemical stability of progesterone significantly. Moreover the polymeric additives improved the skin permeation 1.24- and 1.63-fold and decreased the skin retention in relation to the pure microemulsion. The polymer-stabilized progesterone microemulsions are interesting vehicles for skin application of progesterone.
研究了孕酮对由非离子表面活性剂聚氧乙烯-10-十二烷基醚、三丁酸甘油酯和水组成的水包油型微乳液物理化学行为的影响。结果发现，孕酮对液滴大小、ζ电位、电导率和pH值均无显著影响。然而，在6个月的储存期内，孕酮的化学稳定性不足。因此，向含孕酮的微乳液中添加了两种不同的聚合物试剂，即二氧化硅和聚合物乳化剂。这些聚合物显著提高了孕酮的化学稳定性。此外，与纯微乳液相比，聚合物添加剂使皮肤渗透率提高了1.24倍和1.63倍，并降低了皮肤滞留率。聚合物稳定的孕酮微乳液是用于孕酮皮肤给药的有趣载体。
