Chen X, Chen Z, Chen H
Department of Internal Medicine.
Hua Xi Yi Ke Da Xue Xue Bao. 1991 Jun;22(2):148-52.
The changes of blood viscoelasticity and apparent viscosities at low shear rate (0.512 S-1) and high shear rate (51.2 S-1) were studied in 61 patients with various severity of chronic cor pulmonale (CCP). The relation between blood viscoelasticity and apparent viscosities and PaO2 and PaCO2 was investigated and the data were collected before and after treatment. Grouped data: Group 1. A total of 61 patients with CCP were studied, 10 of them died during hospitalization. Sixty-one patients at the acute stage were divided into mild, severe and dead sub groups. Twenty-nine patients were improved after treatment. Group 2. Control group (74 normal people) matched group 1 in sex and age. The results demonstrated that eta 0.512, eta 51.2 and eta' were slightly increased in the mild group, but HCT, eta 0.512, eta 51.2, AI, eta' and eta" were elevated more significantly in the severe group. All variables mentioned above of died patients were elevated more remarked than that of the mild group. HCT, eta" in dead patients were slightly higher than those in severe group (P less than 0.05-0.01). It was clear that the more severe the patient, the more increased the hematocrit and RBC aggregation, the less the RBC deformability. HCT would be elevated when PaO2 was below 8 kPa (60 mmHg) and the HCT, eta 0.512, eta', eta" increased significantly (P less than 0.05-0.01) when PaCO2 was over 6.65 kPa (50 mmHg). There was a positive linear correlation between eta 0.512 and PaCO2.(ABSTRACT TRUNCATED AT 250 WORDS)
对61例不同严重程度的慢性肺心病（CCP）患者，研究了其血液粘弹性及低切变率（0.512 S-1）和高切变率（51.2 S-1）下的表观粘度变化。研究了血液粘弹性和表观粘度与动脉血氧分压（PaO2）和动脉血二氧化碳分压（PaCO2）之间的关系，并在治疗前后收集数据。分组数据：第1组。共研究61例CCP患者，其中10例在住院期间死亡。61例急性期患者分为轻度、重度和死亡亚组。29例患者治疗后病情改善。第2组。对照组（74名正常人）在性别和年龄上与第1组匹配。结果表明，轻度组的η0.512、η51.2和η'略有升高，但重度组的血细胞比容（HCT）、η0.512、η51.2、聚集指数（AI）、η'和η''升高更显著。上述所有变量在死亡患者中比轻度组升高更明显。死亡患者的HCT、η''略高于重度组（P<0.05-0.01）。显然，患者病情越严重，血细胞比容和红细胞聚集增加越多，红细胞变形性越小。当PaO2低于8 kPa（60 mmHg）时HCT会升高，当PaCO2超过6.65 kPa（50 mmHg）时，HCT、η0.512、η'、η''显著升高（P<0.05-0.01）。η0.512与PaCO2之间存在正线性相关。（摘要截于250字）
