Bossard Céline, Souazé Frédérique, Jarry Anne, Bezieau Stéphane, Mosnier Jean-François, Forgez Patricia, Laboisse Christian L
INSERM, U539, Nantes, F-44035 France.
Peptides. 2007 Oct;28(10):2030-5. doi: 10.1016/j.peptides.2007.06.030. Epub 2007 Jul 25.
We investigated the expression of the neurotensin high-affinity receptor 1 (NTS1) during inflammatory bowel disease (IBD)-related colorectal oncogenesis, in colonic samples from 30 patients with IBD-related adenocarcinomas, dysplasias, and inflammatory mucosa (IM). The percentage of NTS1-positive epithelial cells progressively increased from the inflammatory condition to adenocarcinoma and was significantly higher in adenocarcinomas than in IM (p=0.0169). In parallel, the percentage of neurotensin (NT)-positive epithelial cells increased during the IBD-related oncogenesis. Finally, as NTS1 is a ss-catenin inducible gene, we found that a number of preneoplastic lesions and adenocarcinomas co-expressed NTS1 and beta-catenin without NT expression. Therefore, this study suggests two pathways of NTS1 overexpression during IBD-related oncogenesis: one triggered by NT overexpression, and a second associated with an activation of the APC/beta-catenin pathway, these two pathways being not mutually exclusive.
我们研究了神经降压素高亲和力受体1（NTS1）在炎症性肠病（IBD）相关结直肠癌发生过程中的表达，研究对象为30例患有IBD相关腺癌、发育异常和炎症性黏膜（IM）的患者的结肠样本。NTS1阳性上皮细胞的百分比从炎症状态到腺癌逐渐增加，且腺癌中的该百分比显著高于IM（p = 0.0169）。同时，神经降压素（NT）阳性上皮细胞的百分比在IBD相关肿瘤发生过程中增加。最后，由于NTS1是一种β-连环蛋白诱导基因，我们发现一些癌前病变和腺癌共表达NTS1和β-连环蛋白，但无NT表达。因此，本研究提示了IBD相关肿瘤发生过程中NTS1过表达的两条途径：一条由NT过表达触发，另一条与APC/β-连环蛋白途径的激活有关，这两条途径并非相互排斥。
