Gerbaudo Victor H, Julius Barry
Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
Eur J Radiol. 2007 Dec;64(3):401-5. doi: 10.1016/j.ejrad.2007.08.013. Epub 2007 Sep 17.
To evaluate the structural and metabolic characteristics of atelectasis in FDG-PET/CT.
Twenty one consecutive patients (13 males, 8 females, median age 67 years) with CT features of atelectasis, undergoing PET/CT imaging for preoperative staging of histologically proven malignancies (20 lung cancer and 1 ovarian cancer metastasis to lung), were included in the study.
Hounsfield units of atelectasis (-383.58+/-189, range -631 to 82) were significantly higher than in normal lung (-756+/-67.46, range -839 to -555; P=0.0001), and lower than in malignant tissue (35+/-19, range 4-77; P=0.0001). The main patterns of FDG uptake observed in atelectasis were diffuse and homogenous. The standard uptake value (SUV) in atelectasis was low to moderate (SUV(avg): 1.13+/-0.50; SUV(max): 1.44+/-0.54), and generally lower than in tumor tissue (SUV(avg): 6.25+/-3.58, range 2.0-16.5), but always higher than in normal lung (0.56+/-0.18 and 0.70+/-0.23, respectively) (P=0.0001). There was a positive correlation between the density of atelectatic lesions and the degree of uptake, with no relationship to size.
There is a positive relationship between the density of collapsed lung and the intensity of FDG uptake. FDG uptake in atelectasis is higher than in normal lung, and generally lower than in tumor tissue.
评估FDG-PET/CT中肺不张的结构和代谢特征。
连续纳入21例具有肺不张CT特征的患者（13例男性，8例女性，中位年龄67岁），这些患者因组织学证实的恶性肿瘤（20例肺癌和1例卵巢癌肺转移）术前行PET/CT成像。
肺不张的Hounsfield单位（-383.58±189，范围-631至82）显著高于正常肺组织（-756±67.46，范围-839至-555；P=0.0001），且低于恶性组织（35±19,范围4至77；P=0.0001）。肺不张中观察到的FDG摄取主要模式为弥漫性和均匀性。肺不张的标准摄取值（SUV）为低至中度（SUV(平均)：1.13±0.50；SUV(最大)：1.44±0.54），通常低于肿瘤组织（SUV(平均)：6.25±3.58，范围2.0至16.5），但始终高于正常肺组织（分别为0.56±0.18和0.70±0.23）（P=0.0001）。肺不张病变密度与摄取程度之间存在正相关，与大小无关。
萎陷肺的密度与FDG摄取强度之间存在正相关。肺不张中的FDG摄取高于正常肺组织，且通常低于肿瘤组织。
