Lindegaard J, Gerard J P, Sun Myint A, Myerson R, Thomsen H, Laurberg S
Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Clin Oncol (R Coll Radiol). 2007 Nov;19(9):738-41. doi: 10.1016/j.clon.2007.07.013. Epub 2007 Sep 17.
Although contact radiotherapy was developed 70 years ago, and is highly effective with cure rates of over 90% for early rectal cancer, there are few centres that offer this treatment today. One reason is the lack of replacement of ageing contact X-ray machines, many of which are now over 30 years old. To address this problem, the International Contact Radiotherapy Evaluation (ICONE) group was formed at a meeting in Liverpool in 2005 with the aim of developing a new contact X-ray unit and to establish clinical protocols that would enable the new machine to safely engage in the treatment of rectal cancer. As a result of these efforts, a European company is starting production of the new Papillon RT-50 machine, which will be available shortly. In addition, the ICONE group is planning an observational study on contact X-ray and transanal endoscopic microsurgery (CONTEM) for curative treatment of rectal cancer. This protocol will ensure standardised diagnostic procedures, patient selection and treatment in centres across the world and the data will be collected prospectively for analysis and audit. It is hoped that the CONTEM trial will provide the scientific evidence that is needed to obtain a broader acceptance of local contact radiotherapy as a treatment option for selected cases with early stage rectal cancer.
尽管接触放射疗法在70年前就已开发出来，对早期直肠癌的治愈率超过90%，疗效显著，但如今提供这种治疗的中心却寥寥无几。原因之一是老化的接触式X光机缺乏更新换代，其中许多现已使用超过30年。为解决这一问题，国际接触放射疗法评估（ICONE）小组于2005年在利物浦的一次会议上成立，旨在研发一种新型接触式X光设备，并制定临床方案，使新机器能够安全地用于直肠癌治疗。经过这些努力，一家欧洲公司开始生产新型帕皮隆RT - 50机器，该机器不久后将可供使用。此外，ICONE小组正在计划一项关于接触式X光与经肛门内镜显微手术（CONTEM）治疗直肠癌的观察性研究。该方案将确保世界各地的中心在诊断程序、患者选择和治疗方面实现标准化，数据将前瞻性收集以进行分析和审核。希望CONTEM试验能提供科学证据，使局部接触放射疗法作为早期直肠癌特定病例的一种治疗选择得到更广泛的认可。
