De Tiège Xavier, Rozenberg Flore, Héron Bénédicte
Department of Paediatric Neurology, ULB-Hôpital Erasme, Brussels, Belgium.
Eur J Paediatr Neurol. 2008 Mar;12(2):72-81. doi: 10.1016/j.ejpn.2007.07.007. Epub 2007 Sep 17.
Clinical and basic science research carried out in recent years into herpes simplex encephalitis (HSE) have shown that the concept of a "classical" picture of HSE in children is now outdated and that our current knowledge of the disease is probably only the tip of an iceberg. Indeed, increasing evidence supports the existence of a wider range of pathophysiological mechanisms, clinical presentations and disease progressions in paediatric HSE. This paper reviews the clinical, biological and radiological data available and redefines the spectrum of HSE in children. Full understanding of the condition should improve the management of suspected cases and decrease the morbidity and the mortality associated with this disease.
近年来针对单纯疱疹病毒性脑炎（HSE）开展的临床及基础科学研究表明，儿童HSE“典型”表现的概念现已过时，而且我们目前对该疾病的了解可能只是冰山一角。事实上，越来越多的证据支持小儿HSE存在更广泛的病理生理机制、临床表现和疾病进展情况。本文回顾了现有的临床、生物学和放射学数据，并重新界定了儿童HSE的范围。对该病症的全面了解应能改善疑似病例的管理，并降低与该疾病相关的发病率和死亡率。
