Elias M K, de Wolf J T, Blom N, Rijskamp L, Halie R M, Smit Sibinga C T
Red Cross Blood Bank Groningen-Drenthe, The Netherlands.
J Clin Apher. 1991;6(3):143-9. doi: 10.1002/jca.2920060304.
"Leukocyte-depleted" platelet concentrates (LD-SDPC) were prepared by cotton-wool and by polyester filtration of "leukocyte-poor" PC collected by the elutriation technique. The storage characteristics of LD-SDPC were comparable to those of the filtered pools of multiple donor platelet concentrates (LD-MDPC). However, LD-SDPC were less activated and less damaged than LD-MDPC over a 7-day storage period, as evidenced by beta-thromboglobin percent release and lactic dehydrogenase percent leakage in both products. LD-SDPC were prophylactically transfused to 12 thrombocytopenic patients; the mean bleeding time was shortened from 12 min 20 sec to 4 min 39 sec. Corrected count increment (CCI) was 22.8 at 1 hr and 14.1 at 24 hr compared to 15.5 and 10.0, respectively, with standard PCs.
“白细胞去除”血小板浓缩物（LD - SDPC）通过棉絮过滤以及对采用淘洗技术收集的“白细胞减少”的血小板浓缩物进行聚酯过滤来制备。LD - SDPC的储存特性与多个供体血小板浓缩物的过滤混合池（LD - MDPC）相当。然而，在7天的储存期内，LD - SDPC比LD - MDPC的活化程度更低且损伤更小，这在两种产品的β - 血小板球蛋白释放百分比和乳酸脱氢酶泄漏百分比中得到了证实。对12名血小板减少症患者预防性输注LD - SDPC；平均出血时间从12分20秒缩短至4分39秒。与标准血小板浓缩物分别为15.5和10.0相比，校正计数增加值（CCI）在1小时时为22.8，在24小时时为14.1。
