Saito K, Motoyama N, Dauterman W C
North Carolina State University, Department of Toxicology, Raleigh 27695.
J Econ Entomol. 1991 Dec;84(6):1635-7. doi: 10.1093/jee/84.5.1635.
A colony of azamethiphos-resistant house flies, Musca domestica (L.), was obtained from Denmark and further selected in the laboratory with azamethiphos for four generations. LD50s for various insecticides were determined and compared with those of a susceptible house fly strain. The selected flies showed cross-resistance to all insecticides evaluated. The flies were highly resistant to most organophosphorus, carbamate, and chlorinated hydrocarbon insecticides except prothiophos, p,p'-DDT, and the pyrethroids. We conclude that the main mechanisms responsible for resistance are presumed to be factors other than acetylcholinesterase sensitivity and nerve sensitivity due to knockdown resistance.
从丹麦获得了一群对甲胺磷具有抗性的家蝇（Musca domestica (L.)），并在实验室中用甲胺磷进一步筛选了四代。测定了各种杀虫剂的半数致死剂量（LD50），并与敏感家蝇品系的LD50进行了比较。筛选出的家蝇对所有评估的杀虫剂均表现出交叉抗性。除丙硫磷、p,p'-滴滴涕和拟除虫菊酯外，这些家蝇对大多数有机磷、氨基甲酸酯和氯代烃类杀虫剂具有高度抗性。我们得出结论，导致抗性的主要机制据推测是除乙酰胆碱酯酶敏感性和击倒抗性引起的神经敏感性之外的其他因素。
