Dickson K A, Harding R
Department of Physiology, Monash University, Clayton, Victoria, Australia.
J Dev Physiol. 1991 Aug;16(2):105-13.
Our aim was to measure the compliance of the liquid-filled lungs (CL), and the compliance of the chest wall (CW) in fetal sheep in utero. CL and CW were measured in 6 fetuses. The compliance of the lungs and chest wall combined (respiratory system, Crs) was measured in 9 fetuses. Pressure differences across the lungs (PL), chest wall (PW) and respiratory system (Prs) were measured while the lungs were deflated and inflated with liquid from their resting lung liquid volume (V1). V1 was measured using an indicator dilution technique. Specific compliance values were obtained by normalizing the values of CL, CW and Crs with respect to values of V1. From values obtained during stepwise inflation from V1, specific compliances (ml/cm H2O/ml of lung liquid) were: lungs, 0.22 +/- 0.02; chest wall, 0.41 +/- 0.07; respiratory system, 0.13 +/- 0.01. Specific compliances of the lungs, chest wall and respiratory system did not change significantly with advancing gestational age from 120 to 143 days. Our baseline data will be valuable in assessing the in utero progress of the structural development of the lungs following manipulations known to cause altered lung growth.
我们的目的是测量未出生胎羊中充满液体的肺的顺应性（CL）以及胸壁的顺应性（CW）。对6只胎儿测量了CL和CW。对9只胎儿测量了肺与胸壁联合的顺应性（呼吸系统，Crs）。在肺从其静息肺液体量（V1）放气和充液时，测量肺（PL）、胸壁（PW）和呼吸系统（Prs）上的压力差。V1采用指示剂稀释技术测量。通过将CL、CW和Crs的值相对于V1的值进行归一化来获得比顺应性值。从V1开始逐步充液过程中获得的值来看，比顺应性（毫升/厘米水柱/毫升肺液）分别为：肺，0.22±0.02；胸壁，0.41±0.07；呼吸系统，0.13±0.01。从妊娠120天到143天，肺、胸壁和呼吸系统的比顺应性并未随胎龄增加而发生显著变化。我们的基线数据对于评估已知会导致肺生长改变的操作后肺结构发育的子宫内进展情况将具有重要价值。
