Palecek F, Jezová E
Institute of Pathological Physiology, Faculty of Paediatrics, Charles University, Prague.
Physiol Bohemoslov. 1988;37(1):39-48.
The experiments were performed on male rats of the Wistar strain under urethane anaesthesia (1.3 g/kg i.p.). Changes of oesophageal and tracheal pressures were registered in a group of 30 spontaneously breathing, supine rats, of 295 +/- 13 g average body weight during lung inflations with 1-5 ml of air. In another group of 25 rats of 70 +/- 6 g average body weight (young rats) we made the measurements during inflation with volumes 0.5-2 ml. The measurements were also performed in a group of 10 paralyzed, ventilated rats with 347 +/- 24 g average body weight and inflations 1-5 ml. Compliance of the lungs (CL), chest wall (CW) and of the respiratory system (Crs) was calculated from the linear part of the pressure-volume curve during inflation. The results indicate: 1. Cw is significantly (p less than 0.001) higher in young (134.7 ml.kPa-1.kg-1) than in adult rats (44.1 ml.kPa-1.kg-1). CL (related to body weight) is not significantly different in young and adult rats. 2. Cw is significantly (p less than 0.001) higher than CL. 3. No difference was observed in CLs Cw and Crs between paralyzed and spontaneously breathing animals.
实验在乌拉坦麻醉（腹腔注射1.3 g/kg）下的雄性Wistar品系大鼠身上进行。在一组30只平均体重295±13 g、自主呼吸、仰卧的大鼠中，用1 - 5 ml空气进行肺充气时记录食管和气管压力变化。在另一组25只平均体重70±6 g的幼鼠中，用0.5 - 2 ml的容量进行充气时进行测量。在一组10只平均体重347±24 g、瘫痪并通气的大鼠中，也用1 - 5 ml的充气量进行测量。根据充气过程中压力 - 容积曲线的线性部分计算肺（CL）、胸壁（CW）和呼吸系统（Crs）的顺应性。结果表明：1. 幼鼠（134.7 ml·kPa⁻¹·kg⁻¹）的CW显著高于成年大鼠（44.1 ml·kPa⁻¹·kg⁻¹）（p < 0.001）。幼鼠和成年大鼠的CL（与体重相关）无显著差异。2. CW显著高于CL（p < 0.001）。3. 瘫痪动物和自主呼吸动物的CL、CW和Crs之间未观察到差异。
