伯氏疏螺旋体中纤连蛋白结合蛋白BBK32的表达调控
Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi.
作者信息
He Ming, Boardman Bethany K, Yan Dalai, Yang X Frank
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
J Bacteriol. 2007 Nov;189(22):8377-80. doi: 10.1128/JB.01199-07. Epub 2007 Sep 14.
Abstract
The BBK32 protein binds to host extracellular ligand fibronectin and contributes to the pathogenesis of Borrelia burgdorferi. Here we showed that expression of the BBK32 gene is influenced by multiple environmental factors and that its regulation is governed by the response regulator Rrp2 and RpoN-RpoS (sigma(54)-sigma(S)) sigma cascade in B. burgdorferi.
摘要
BBK32蛋白与宿主细胞外配体纤连蛋白结合，并且在伯氏疏螺旋体的致病过程中发挥作用。在此我们发现，BBK32基因的表达受多种环境因素影响，其调控由伯氏疏螺旋体中的应答调节因子Rrp2以及RpoN-RpoS（σ⁵⁴-σˢ）σ因子级联所控制。
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