Tan P H, Tse G M K, Bay B H
Department of Pathology, Singapore General Hospital, Singapore.
J Clin Pathol. 2008 Jan;61(1):11-9. doi: 10.1136/jcp.2006.046227. Epub 2007 Sep 14.
Breast lesions with mucin represent a broad spectrum of entities, ranging from benign fibrocystic changes with luminal mucin to mucocele-like lesions (MLL), which can be associated with banal epithelial alterations, atypical ductal hyperplasia or ductal carcinoma in situ. Occasionally invasive mucinous carcinoma can be identified in contiguity with MLL. Diagnostic challenges are enumerated, histological differentials are discussed, and a practical approach towards resolving some of these issues is provided. In addition to these lesions with abundant extracellular mucin, there are also conditions that feature stromal mucinous or myxoid material, as well as rare entities that demonstrate both epithelial extracellular and stromal mucin.
伴有黏液的乳腺病变涵盖了广泛的实体，从伴有管腔内黏液的良性纤维囊性变到黏液囊肿样病变（MLL），后者可伴有普通上皮改变、非典型导管增生或导管原位癌。偶尔，浸润性黏液癌可与MLL相邻出现。文中列举了诊断挑战，讨论了组织学鉴别，并提供了解决其中一些问题的实用方法。除了这些具有丰富细胞外黏液的病变外，还有一些以间质黏液或黏液样物质为特征的情况，以及罕见的同时具有上皮细胞外黏液和间质黏液的实体。
