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促红细胞生成素治疗与癌症相关性贫血:瑞典最新建议

Erythropoietin therapy and cancer related anaemia: updated Swedish recommendations.

作者信息

Ahlqvist-Rastad Jane, Albertsson Maria, Bergh Jonas, Birgegård Gunnar, Johansson Peter, Jonsson Bertil, Kjellen Elisabeth, Påhlman Sven, Zackrisson Björn, Osterborg Anders

机构信息

Medical Products Agency, Uppsala 751 03, Sweden.

出版信息

Med Oncol. 2007;24(3):267-72. doi: 10.1007/s12032-007-0037-5.

DOI:10.1007/s12032-007-0037-5
PMID:17873301
Abstract

Due to concerns related to treatment with erythropoietin (EPO) and possible negative effects on tumour control, a workshop was organised by the Medical Products Agency of Sweden with the aim to revise national treatment guidelines if needed. In patients with solid tumours, conflicting results have been reported with respect to tumour control and survival. Until further notice it is therefore recommended that EPO should be used restrictively in the treatment of patients with cancer and that the anticipated improvement in quality of life should be evaluated against potential risks.

摘要

由于对促红细胞生成素(EPO)治疗及其对肿瘤控制可能产生的负面影响存在担忧,瑞典医疗产品管理局组织了一次研讨会,目的是在必要时修订国家治疗指南。在实体瘤患者中,关于肿瘤控制和生存率的报道结果相互矛盾。因此,在另行通知之前,建议在癌症患者治疗中限制使用EPO,并且应根据潜在风险评估预期的生活质量改善情况。

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本文引用的文献

1
Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies.促红细胞生成素受体的表达及促红细胞生成素在B细胞恶性肿瘤中的体外功能效应
Clin Cancer Res. 2007 Jun 15;13(12):3536-44. doi: 10.1158/1078-0432.CCR-06-2828.
2
Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia.促红细胞生成素治疗非小细胞肺癌伴疾病相关性贫血的随机、双盲、安慰剂对照试验
J Clin Oncol. 2007 Mar 20;25(9):1027-32. doi: 10.1200/JCO.2006.07.1514. Epub 2007 Feb 20.
3
Effect of treatment with epoetin beta on short-term tumour progression and survival in anaemic patients with cancer: A meta-analysis.
β-促红细胞生成素治疗对癌症贫血患者短期肿瘤进展和生存的影响:一项荟萃分析。
Br J Cancer. 2006 Dec 4;95(11):1467-73. doi: 10.1038/sj.bjc.6603481. Epub 2006 Nov 21.
4
Erythropoietin receptor expression in non-small cell lung carcinoma: a question of antibody specificity.促红细胞生成素受体在非小细胞肺癌中的表达:抗体特异性问题。
Stem Cells. 2007 Mar;25(3):718-22. doi: 10.1634/stemcells.2006-0687. Epub 2006 Nov 16.
5
Do erythropoietin receptors on cancer cells explain unexpected clinical findings?癌细胞上的促红细胞生成素受体能否解释意外的临床发现?
J Clin Oncol. 2006 Oct 10;24(29):4708-13. doi: 10.1200/JCO.2006.06.2737.
6
Erythropoietin administration during primary treatment for locally advanced cervical carcinoma is associated with poor response to radiation.在局部晚期宫颈癌的初始治疗期间给予促红细胞生成素与放疗反应不佳有关。
Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1855-61. doi: 10.1111/j.1525-1438.2006.00709.x.
7
Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients.重组人促红细胞生成素与癌症患者:对57项研究(涵盖9353例患者)的最新荟萃分析
J Natl Cancer Inst. 2006 May 17;98(10):708-14. doi: 10.1093/jnci/djj189.
8
Anti-Epo receptor antibodies do not predict Epo receptor expression.抗促红细胞生成素受体抗体无法预测促红细胞生成素受体的表达。
Blood. 2006 Mar 1;107(5):1892-5. doi: 10.1182/blood-2005-10-4066. Epub 2005 Oct 25.
9
Darbepoetin alfa for the treatment of chemotherapy-induced anemia: disease progression and survival analysis from four randomized, double-blind, placebo-controlled trials.聚乙二醇化促红细胞生成素α用于治疗化疗所致贫血:四项随机、双盲、安慰剂对照试验的疾病进展及生存分析
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J Clin Oncol. 2005 Sep 1;23(25):5960-72. doi: 10.1200/JCO.2005.06.150. Epub 2005 Aug 8.