Misirlioglu Cem H, Demirkasimoglu Taciser, Kucukplakci Bulent, Sanri Ergun, Altundag Kadri
Department of Radiation Oncology, Ankara Oncology Hospital, Ankara, Turkey.
Med Oncol. 2007;24(3):308-11. doi: 10.1007/s12032-007-0006-z.
Combined use of pentoxifylline and vitamin E is reported to reduce radiation-induced toxicity in normal tissues at molecular level. We plan to evaluate the role of combined use of pentoxifylline (PTX) and alpha-tocopherol (vitamin E; Vit E) for minimizing radiation-induced lung toxicity. A total of 91 lung cancer patients were randomized. Among them, 44 received PTX (400 mg three times a day orally and Vit E 300 mg twice a day orally during the entire period of radiotherapy. PTX and Vit E were further administered at doses of 400 mg once a day and 300 mg once a day, respectively for 3 months after radiotherapy. A total of 47 patients were assigned as a control group. Radiation related acute and late toxicities are evaluated by radiation RTOG/EORTC toxicity scale. Median age was 59 (range, 41-75). Median follow-up was 13 months (range, 3-28 months). Radiation-induced lung toxicity was more frequent in control group for all phases than in pentoxifylline and alpha-tocopherol group (acute phase, P = 0.042, subacute phase P = 0.0001, late phase P = 0.256). PTX and Vit E combination might be considered especially in patients with lung cancer who receive concurrent chemo-radiotherapy, or have a poor respiratory function tests.
据报道，己酮可可碱与维生素E联合使用可在分子水平上降低正常组织的辐射诱导毒性。我们计划评估己酮可可碱（PTX）与α-生育酚（维生素E；Vit E）联合使用对减轻辐射诱导的肺毒性的作用。共有91例肺癌患者被随机分组。其中，44例患者在整个放疗期间接受PTX（每日口服3次，每次400 mg）和Vit E（每日口服2次，每次300 mg）。放疗后3个月，PTX和Vit E分别以每日1次、每次400 mg和每日1次、每次300 mg的剂量进一步给药。共有47例患者被分配为对照组。通过放射肿瘤学组（RTOG）/欧洲癌症研究与治疗组织（EORTC）毒性量表评估与辐射相关的急性和晚期毒性。中位年龄为59岁（范围41 - 75岁）。中位随访时间为13个月（范围3 - 28个月）。在所有阶段，对照组的辐射诱导肺毒性均比己酮可可碱和α-生育酚组更频繁（急性期，P = 0.042；亚急性期，P = 0.0001；晚期，P = 0.256）。尤其是对于接受同步放化疗或呼吸功能测试较差的肺癌患者，可能应考虑使用PTX和Vit E联合治疗。
