Ozturk Berrin, Egehan Ibrahim, Atavci Sevil, Kitapci Mehmet
Department of Radiation Oncology, Gazi University Medical Faculty, Ankara, Turkey.
Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):213-9. doi: 10.1016/s0360-3016(03)01444-5.
Pentoxifylline (Ptx) is thought to be helpful in preventing radiotoxicity by inhibiting platelet aggregation and tumor necrosis factor. We assessed whether prophylactic use of Ptx could prevent early and late normal lung tissue damage due to radiotherapy in a double-blind, randomized trial.
A total of 40 patients with lung or breast cancer were randomized to receive Ptx (400 mg) or a placebo, 3 times daily, during the entire period of radiotherapy. We used the late effects normal tissue-subjective, objective, management, and analytic (LENT-SOMA) scale to evaluate and compare toxicity, including the findings of pulmonary function tests and radiologic and scintigraphic evaluations performed before and at 3 and 6 months of follow-up.
According to the LENT score, a statistically significant difference was found between the two groups in favor of Ptx (p = 0.016). The difference in diffusing capacity of the lung for carbon monoxide and regional perfusion scan results were found to be statistically significant between the groups at 3 and 6 months (p <0.05). The use of Ptx resulted in a noticeable reduction in the higher degrees of lung injury detected radiologically.
Our study showed a significant protective effect of Ptx for both early and late lung radiotoxicity. We recommend the prophylactic use of Ptx, finding it to be safe and effective.
己酮可可碱（Ptx）被认为可通过抑制血小板聚集和肿瘤坏死因子来预防放射毒性。我们在一项双盲随机试验中评估了预防性使用Ptx是否能预防放疗引起的早期和晚期正常肺组织损伤。
总共40例肺癌或乳腺癌患者被随机分为两组，在整个放疗期间，一组每日3次接受Ptx（400毫克）治疗，另一组接受安慰剂治疗。我们使用正常组织晚期效应的主观、客观、管理和分析（LENT-SOMA）量表来评估和比较毒性，包括肺功能测试结果以及在随访3个月和6个月时进行的放射学和闪烁扫描评估结果。
根据LENT评分，两组之间存在统计学上的显著差异，Ptx组更具优势（p = 0.016）。在3个月和6个月时，两组之间一氧化碳肺弥散量和区域灌注扫描结果的差异具有统计学意义（p <0.05）。使用Ptx导致放射学检测到的较高程度肺损伤明显减少。
我们的研究表明Ptx对早期和晚期肺放射毒性均具有显著的保护作用。我们建议预防性使用Ptx，因为它安全有效。
