多发性骨髓瘤患者中自然杀伤细胞活性随临床分期的降低。
Clinical stage-depending decrease of NK cell activity in multiple myeloma patients.
作者信息
Jurisic Vladimir, Srdic Tatjana, Konjevic Gordana, Markovic Olivera, Colovic Milica
机构信息
Pathophysiology Department, School of Medicine, University of Kragujevac, Kragujevac 34 000, Serbia.
出版信息
Med Oncol. 2007;24(3):312-7. doi: 10.1007/s12032-007-0007-y.
Natural killer cells, as an important subpopulation of cells of the innate immune system have an essential role in defense of the rise and spread of malignancy. These cells have a CD3-CD16 + CD56+ phenotype and they are functionally defined by their ability to lyses tumor cells. We here show that decrease of NK cell activity was significantly associated with advanced clinical stage, increased lactate dehydrogenase (LDH), percentage infiltration of bone marrow with plasma cells, and beta-2 microglobulin. The patients with higher NK cell activity at presentation after receiving VAD protocol have better cumulative survival in comparison with those with low NK cell activity.
自然杀伤细胞作为先天性免疫系统细胞的一个重要亚群，在抵御恶性肿瘤的发生和扩散中起着至关重要的作用。这些细胞具有CD3-CD16 + CD56+表型，其功能通过裂解肿瘤细胞的能力来定义。我们在此表明，自然杀伤细胞活性的降低与晚期临床分期、乳酸脱氢酶（LDH）升高、骨髓浆细胞浸润百分比以及β2微球蛋白显著相关。接受VAD方案后就诊时自然杀伤细胞活性较高的患者与自然杀伤细胞活性较低的患者相比，具有更好的累积生存率。
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