Spiliopoulou Polyxeni, Rousakis Pantelis, Panteli Chrysanthi, Eleutherakis-Papaiakovou Evangelos, Migkou Magdalini, Kanellias Nikolaos, Ntanasis-Stathopoulos Ioannis, Malandrakis Panagiotis, Theodorakakou Foteini, Fotiou Despina, Terpos Evangelos, Gavriatopoulou Maria, Tsitsilonis Ourania E, Kastritis Efstathios, Dimopoulos Meletios Athanasios, Terzis Gerasimos
Sports Performance Laboratory, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece.
Flow Cytometry Unit, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Scand J Med Sci Sports. 2025 Feb;35(2):e70020. doi: 10.1111/sms.70020.
The purpose of the study was to investigate the effects of exercise training on the bone marrow immune microenvironment and on minimal residual disease of multiple myeloma patients who completed first-line induction treatment. Eight multiple myeloma patients underwent 5 months of exercise training along with standard medical treatment. Eight age- and sex-matched patients who received medical treatment only, served as controls. Before and after the intervention, white blood cells, red blood cells, and platelets, as well as the percentages of neutrophils, lymphocytes, monocytes, eosinophils, and basophils, were measured in the peripheral blood. Abnormal plasma cells, normal plasma cells, B cells, T cells, NK/NKT cells, monocytes, neutrophils, eosinophils, basophils, mast cells, myeloid progenitors, erythroid progenitors, and erythroblasts were assessed in the bone marrow. Exercise training increased the percentage of blood monocytes (mean difference 3.5% ± 2.6%; p = 0.006), while no change was detected in the control group. In the bone marrow, the CD27+ T cell subset increased (mean difference 18.2% ± 21.9%; p = 0.043) and the ratio of CD27-/CD27+ T lymphocytes decreased (pre: 1.06 ± 0.59; post: 0.76 ± 0.47; p = 0.049) in the exercise group, but remained unaltered in the control group. In conclusion, the study provides evidence that 5 months of exercise training can induce an increase in the percentage of activated T lymphocytes, as shown by the higher expression of the costimulatory CD27 marker. It also suggests that exercise-induced changes in the bone marrow microenvironment may be beneficial in the control of clonal cell proliferation.
本研究的目的是调查运动训练对完成一线诱导治疗的多发性骨髓瘤患者的骨髓免疫微环境和微小残留病的影响。八名多发性骨髓瘤患者在接受标准药物治疗的同时进行了5个月的运动训练。八名年龄和性别匹配、仅接受药物治疗的患者作为对照。干预前后，对外周血中的白细胞、红细胞、血小板以及中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞的百分比进行了测量。对骨髓中的异常浆细胞、正常浆细胞、B细胞、T细胞、NK/NKT细胞、单核细胞、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、髓系祖细胞、红系祖细胞和成红细胞进行了评估。运动训练使血液单核细胞百分比增加（平均差异3.5%±2.6%；p=0.006），而对照组未检测到变化。在骨髓中，运动组的CD27+T细胞亚群增加（平均差异18.2%±21.9%；p=0.043），CD27-/CD27+T淋巴细胞的比例降低（干预前：1.06±0.59；干预后：0.76±0.47；p=0.049），而对照组保持不变。总之，该研究提供了证据表明，5个月的运动训练可诱导活化T淋巴细胞百分比增加，共刺激CD27标志物的较高表达表明了这一点。研究还表明，运动引起的骨髓微环境变化可能有利于控制克隆细胞增殖。
