Mann David R, Bhat Ganapathy K, Ramaswamy Suresh, Stah Christine D, Plant Tony M
Cooperative Reproductive Science Research Center, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310-1495, USA.
Endocrine. 2007 Apr;31(2):125-9. doi: 10.1007/s12020-007-0020-0.
In humans, circulating leptin levels are low in early childhood and rise until puberty, whereas the reverse occurs for the soluble leptin receptor (sOB-R). In women, leptin remains high and sOB-R remains low, but in men leptin declines after adolescence and sOB-R increases. These observations suggest that leptin may regulate the production of sOB-R, and that the increased testosterone in adolescent boys may be responsible for the gender differences in leptin and sOB-R. To test this hypothesis, leptin was administered continuously to agonadal juvenile male monkeys for 16 days. No change in sOB-R was observed. Intact juvenile male monkeys were given pulsatile doses of gonadotropins for a period of 7 weeks to induce precocious puberty and assess the effect on plasma testosterone, leptin, and sOB-R. By 4 weeks testosterone had reached adult levels. No changes were observed in leptin, but by week 4, sOB-R was higher than pretreatment values and remained higher at week 7. These data suggest that leptin may not play a significant role in regulating the production of sOB-R and that gender differences in sOB-R in humans may be driven by the increased production of testosterone at puberty in males.
在人类中，循环瘦素水平在幼儿期较低，直至青春期升高，而可溶性瘦素受体（sOB-R）的情况则相反。在女性中，瘦素水平保持较高而sOB-R水平保持较低，但在男性中，瘦素在青春期后下降而sOB-R增加。这些观察结果表明，瘦素可能调节sOB-R的产生，并且青春期男孩体内睾酮增加可能是导致瘦素和sOB-R性别差异的原因。为了验证这一假设，对性腺功能缺失的幼年雄性猴子连续16天给予瘦素。未观察到sOB-R有变化。对完整的幼年雄性猴子给予脉冲剂量的促性腺激素，持续7周以诱导性早熟，并评估对血浆睾酮、瘦素和sOB-R的影响。到第4周时，睾酮达到成年水平。瘦素未观察到变化，但到第4周时，sOB-R高于预处理值，并在第7周时仍保持较高水平。这些数据表明，瘦素可能在调节sOB-R的产生中不发挥重要作用，并表明人类sOB-R的性别差异可能是由男性青春期睾酮产生增加所驱动的。
