Tubek Sławomir, Tubek Iwona
Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, Prószkowska Street 76, Opole, 45-758, Poland.
Biol Trace Elem Res. 2007 Summer;117(1-3):1-5. doi: 10.1007/BF02698078.
Nephrotoxicity is an undesirable reaction of contrast media used in X-ray or magnetic resonance diagnostics. In addition to a direct toxic effect on renal tubules, the hemodynamic factor is considered to be the main cause of kidney damage and malfunction. The factors that increase the probability of a nephrotoxic effect of contrast media include oldage, diabetes, arterial hypertension, circulatory system insufficiency, neoplastic diseases, and prior kidney damage. Decreased serum zinc is observed in all those conditions. In this article, the influence of contrast media on zinc homeostasis and the possibility of a nephrotoxic reaction caused by these agents is discussed.
肾毒性是X射线或磁共振诊断中使用的造影剂产生的不良反应。除了对肾小管有直接毒性作用外，血流动力学因素被认为是肾脏损伤和功能障碍的主要原因。增加造影剂肾毒性作用可能性的因素包括老年、糖尿病、动脉高血压、循环系统功能不全、肿瘤性疾病和既往肾脏损伤。在所有这些情况下均观察到血清锌降低。本文讨论了造影剂对锌稳态的影响以及这些药物引起肾毒性反应的可能性。
