Balakrishnan Vallath, Chatni Sanjeev, Radhakrishnan Lakshmi, Narayanan Venkateswaran A, Nair Prem
Digestive Diseases Institute, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India.
JOP. 2007 Sep 7;8(5):592-7.
Groove pancreatitis is a rare type of segmental pancreatitis characterized by fibrous scars of the anatomic space between the dorsocranial part of the head of the pancreas, the duodenum, and the common bile duct.
A 40-year-old man, with a past history of chronic alcohol consumption presented with epigastric pain radiating to the back and intermittent vomiting and a weight loss of 9 kg. A CT of the abdomen revealed swelling of the pancreatic head, a hypodense mass and duodenal wall thickening with luminal narrowing. Peripancreatic fluid and dense strands were also seen. Upper gastrointestinal endoscopy revealed an edematous, shiny, reddish raised mucosa having a polypoid appearance with narrowing of the second portion of the duodenum. Histological examination of the duodenal biopsy specimens showed preservation of the crypt-villus ratio, and the submucosa showed Brunner gland hyperplasia. These findings appeared consistent with the diagnosis of groove pancreatitis. Presently, the patient is on conservative medical management with analgesics, proton pump inhibitors and a pancreatic enzyme supplement.
Groove pancreatitis often masquerades as pancreatic head carcinoma. This condition should be kept in mind when making the differential diagnosis between pancreatic masses and duodenal stenosis. In all cases of focal pancreatitis involving the head or uncinate process of the pancreas with involvement of the adjacent duodenum, the possibility of groove pancreatitis should be considered.
沟部胰腺炎是一种罕见的节段性胰腺炎,其特征是胰腺头部背侧颅部、十二指肠和胆总管之间解剖间隙出现纤维瘢痕。
一名40岁男性,有长期饮酒史,出现上腹部疼痛并放射至背部、间歇性呕吐,体重减轻9千克。腹部CT显示胰腺头部肿胀、低密度肿块以及十二指肠壁增厚伴管腔狭窄。还可见胰腺周围积液和致密条索影。上消化道内镜检查显示十二指肠第二部狭窄处有水肿、发亮、微红的隆起黏膜,呈息肉样外观。十二指肠活检标本的组织学检查显示隐窝 - 绒毛比例正常,黏膜下层显示布伦纳腺增生。这些发现与沟部胰腺炎的诊断相符。目前,患者正在接受保守药物治疗,使用镇痛药、质子泵抑制剂和胰酶补充剂。
沟部胰腺炎常伪装成胰腺头部癌。在鉴别胰腺肿块和十二指肠狭窄时应考虑到这种情况。在所有累及胰腺头部或钩突且相邻十二指肠受累的局灶性胰腺炎病例中,均应考虑沟部胰腺炎的可能性。