Ceylan Alper, Ileri Fikret, Uslu Sabri, Asal Korhan, Ural Ahmet
Department of Otolaryngology, Medicine Faculty of Gazi University, Ankara, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2007;17(3):127-9.
We investigated the hemodynamic effects of local anesthetics with adrenaline used before septal surgery.
In a prospective, controlled design, administration of local anesthetics was performed with and without adrenaline in 39 patients and 10 patients, respectively, undergoing septal surgery. Plasma adrenaline concentrations were measured before anesthesia, and after 2, 5, and 10 minutes from anesthesia. The patients were monitored with respect to pulse rate, electrocardiographic findings, and blood pressure.
Preoperative plasma adrenaline levels were similar in patients receiving local anesthetics with or without adrenaline (0.8 nmol/l vs 0.7 nmol/l). Following adrenaline administration, adrenaline levels showed significant increases to 2.2, 1.9, and 1.7 nmol/l after 2, 5, and 10 minutes, respectively (p<0.001), whereas they remained similar in the control group. No side effects related to adrenaline use were detected.
Despite systemic absorption of local injections, adrenaline-related side effects during septal surgery are extremely rare when the patients are closely monitored.
我们研究了鼻中隔手术前使用含肾上腺素的局部麻醉剂的血流动力学效应。
在一项前瞻性对照设计中，分别对39例和10例接受鼻中隔手术的患者在使用和不使用肾上腺素的情况下进行局部麻醉剂给药。在麻醉前以及麻醉后2、5和10分钟测量血浆肾上腺素浓度。对患者的脉搏率、心电图结果和血压进行监测。
接受含或不含肾上腺素局部麻醉剂的患者术前血浆肾上腺素水平相似（0.8纳摩尔/升对0.7纳摩尔/升）。给予肾上腺素后，肾上腺素水平在2、5和10分钟后分别显著升高至2.2、1.9和1.7纳摩尔/升（p<0.001），而对照组中该水平保持相似。未检测到与使用肾上腺素相关的副作用。
尽管局部注射药物会被全身吸收，但在密切监测患者的情况下，鼻中隔手术期间与肾上腺素相关的副作用极为罕见。
