Ichijima Hideji, Cavanagh H Dwight
Menicon Co., Ltd., Nagoya, Japan.
Eye Contact Lens. 2007 Sep;33(5):216-23. doi: 10.1097/01.icl.0000254523.63767.05.
To show the superiority of hyper-Dk rigid gas-permeable (RGP) lenses to silicone hydrogels from the viewpoint of total oxygen supply to the entire cornea.
The simple model of fitting the cornea with a contact lens was divided into 1-mm steps from the center to the limbus, and the area of concentric ring zones was calculated. Precorneal oxygen tension (PO2) for each zone was calculated using the Brennan oxygen calculator, and by taking into account the area uncovered by the RGP lens and the lens thickness, the average precorneal PO2 was mathematically compared for wear of silicone hydrogel and RGP lenses.
The average precorneal PO2 of the RGP lens was superior to that of the silicone hydrogel lens under open- and closed-eye conditions because the precorneal PO2 in the uncovered areas of the cornea can supply large contributions. The PO2 of a silicone hydrogel lens with 125 x 10(-9) of oxygen transmissibility at center thickness (Dk/t(c)) was estimated as 45 mm Hg under closed-eye conditions. At the same value, the Dk/t(c) of an RGP lens with a diameter of 11.0 mm was estimated to be 90 x 10(-9).
To minimize hypoxia in extended wear, clinicians should consider that an RGP lens with a Dk/t(c) value of only 90 x 10(-9) is equivalent to a silicone hydrogel lens with a Dk/t(c) value of 125 x 10(-9), and even high Dk/t(c) values for RGP lenses will provide more total oxygen to the entire cornea than their hybrid silicone hydrogel counterparts.
从向整个角膜提供总氧量的角度,展示高透氧性硬性透气性(RGP)镜片相对于硅水凝胶镜片的优越性。
将隐形眼镜适配角膜的简单模型从中心到角膜缘按1毫米步长划分,计算同心环形区域的面积。使用布伦南氧气计算器计算每个区域的角膜前氧分压(PO2),并考虑RGP镜片未覆盖的面积和镜片厚度,通过数学方法比较硅水凝胶镜片和RGP镜片佩戴时的平均角膜前PO2。
在睁眼和闭眼条件下,RGP镜片的平均角膜前PO2均优于硅水凝胶镜片,因为角膜未覆盖区域的角膜前PO2能提供很大贡献。中心厚度(Dk/t(c))为125×10⁻⁹的硅水凝胶镜片在闭眼条件下的PO2估计为45毫米汞柱。在相同数值下,直径为11.0毫米的RGP镜片的Dk/t(c)估计为90×10⁻⁹。
为尽量减少长时间佩戴时的缺氧情况,临床医生应考虑,Dk/t(c)值仅为90×10⁻⁹的RGP镜片等同于Dk/t(c)值为125×10⁻⁹的硅水凝胶镜片,而且对于RGP镜片而言,即使是高Dk/t(c)值也会比其对应的混合硅水凝胶镜片为整个角膜提供更多的总氧量。