Annamraju Siddhartha, Sheitman Brian, Saik Susan, Stephenson Anne
Dorothea Dix Hospital, Raleigh, NC 27603, USA.
J Clin Psychopharmacol. 2007 Oct;27(5):479-83. doi: 10.1097/jcp.0b013e31814e5e68.
Recently, there has been an increased recognition of the association of clozapine with myocarditis and myocardiopathy. Commonly used diagnostic tests have very limited sensitivity in diagnosing this potentially life-threatening complication. We present 3 case reports of clozapine-induced myocarditis/cardiomyopathy that illustrate the development of a combined approach involving a clinical questionnaire and diagnostic testing at our hospital. This combination approach helped in the early recognition and successful treatment of clozapine myocarditis in one of our patients. Given the increasing recognition of this adverse reaction, we felt it timely to report our experience in diagnosing and treating this clinical syndrome.
最近，氯氮平与心肌炎和心肌病之间的关联已得到更多认识。常用的诊断测试在诊断这种潜在的危及生命的并发症方面敏感性非常有限。我们报告3例氯氮平所致心肌炎/心肌病的病例，这些病例说明了我们医院采用临床问卷和诊断测试相结合方法的过程。这种联合方法有助于早期识别并成功治疗我们其中一位患者的氯氮平相关性心肌炎。鉴于对这种不良反应的认识不断增加，我们认为及时报告我们在诊断和治疗这种临床综合征方面的经验很有必要。
