Gendeh B S, Said H, Gibb A G, Aziz N S, Zahir Z M
ENT Department, Faculty of Medicine, National University of Malaysia, Kuala Lumpur.
J Laryngol Otol. 1991 Dec;105(12):999-1001. doi: 10.1017/s0022215100118055.
In a prospective study on 47 patients, 16 mg of gentamicin per two litres dialysate was administered intraperitoneally at every cycle of intermittent peritoneal dialysis, carried out over the course of several days. Serum gentamicin sampling, pure tone audiometry and caloric tests were performed before and during the treatment. The gentamicin levels reached at the end of the thirtieth cycle were observed to be low. In view of this, the risk of acute ototoxicity was considered to be minimal. This was confirmed by the absence of clinical audiometric or vestibulometric evidence of toxicity.
在一项针对47名患者的前瞻性研究中，在为期数天的间歇性腹膜透析的每个周期，每两升透析液腹腔内注射16毫克庆大霉素。在治疗前和治疗期间进行血清庆大霉素采样、纯音听力测定和冷热试验。观察到在第三十周期结束时庆大霉素水平较低。鉴于此，急性耳毒性风险被认为极小。临床听力测定或前庭功能测定未发现毒性证据，证实了这一点。
