van der Hulst R J, Boeschoten E W, Nielsen F W, Struijk D G, Dreschler W D, Tange R A
Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, The Netherlands.
ORL J Otorhinolaryngol Relat Spec. 1991;53(1):19-22. doi: 10.1159/000276178.
Ototoxicity affects the higher frequencies first and extends to the lower frequencies during continuation of the ototoxic treatment. Peritonitis due to continuous ambulatory peritoneal dialysis (CAPD) regularly demands ototoxic antibiotic treatment, e.g. with gentamicin and vancomycin. In this study ultra-high frequency audiometry (10-20 kHz), 'normal' audiometry (0.125-8 kHz) and registration of blood concentrations of the antibiotics were used to assess ototoxic hearing loss during treatment of CAPD patients with peritonitis.
耳毒性首先影响高频，在耳毒性治疗持续期间会扩展至低频。持续性非卧床腹膜透析（CAPD）所致腹膜炎通常需要使用耳毒性抗生素治疗，如庆大霉素和万古霉素。在本研究中，采用超高频听力测定法（10 - 20千赫）、“常规”听力测定法（0.125 - 8千赫）以及抗生素血药浓度测定，以评估CAPD合并腹膜炎患者治疗期间的耳毒性听力损失。
