Chel V, Wijnhoven H A H, Smit J H, Ooms M, Lips P
Verpleeghuis Marienhave, Warmond, The Netherlands.
Osteoporos Int. 2008 May;19(5):663-71. doi: 10.1007/s00198-007-0465-2. Epub 2007 Sep 14.
The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly dose was the least effective.
It is assumed that equivalent daily, weekly or monthly doses of vitamin D3 equally influence vitamin D status. This was investigated in a randomized clinical trial in nursing home residents.
The study was performed in ten nursing homes including 338 subjects (76 male and 262 female), with a mean age of 84 (+/- SD 6.3 years). They received oral vitamin D3 either 600 IU/day, or 4200 IU/week, or 18,000 IU/month or placebo. After 4 months, calcium was added during 2 weeks, 320 mg/day or 640 mg/day or placebo.
serum levels of 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone turnover markers. Statistical approach: linear multilevel analysis.
At baseline, mean serum 25(OH)D was 25.0 nmol/L (SD 10.9), and in 98%, it was lower than 50 nmol/L. After 4 months, mean serum 25(OH)D levels increased to 62.5 nmol/L (after daily vitamin D3 69.9 nmol/L, weekly 67.2 nmol/L and monthly 53.1 nmol/L, P < 0.001 between groups). Median serum PTH levels decreased by 23% (p < 0.001). Bone turnover markers did not decrease. Calcium supplementation had no effect on serum PTH and bone turnover.
Daily vitamin D was more effective than weekly, and monthly administration was the least effective.
在一项针对养老院居民的随机临床试验中，比较了每日口服600国际单位、每周口服4200国际单位和每月口服18000国际单位的维生素D3等效剂量对维生素D状态的影响。每日剂量比每周剂量更有效，而每月剂量效果最差。
假定每日、每周或每月等效剂量的维生素D3对维生素D状态有同等影响。在一项针对养老院居民的随机临床试验中对此进行了研究。
该研究在十家养老院进行，纳入338名受试者（76名男性和262名女性），平均年龄为84岁（标准差6.3岁）。他们接受口服维生素D3，剂量分别为每日600国际单位、每周4200国际单位、每月18000国际单位或安慰剂。4个月后，在2周内添加钙，剂量为每日320毫克或640毫克或安慰剂。
血清25-羟维生素D（25(OH)D）、甲状旁腺激素（PTH）和骨转换标志物水平。统计方法：线性多水平分析。
基线时，血清25(OH)D平均水平为25.0纳摩尔/升（标准差10.9），98%的人低于50纳摩尔/升。4个月后，血清25(OH)D平均水平升至62.5纳摩尔/升（每日服用维生素D3后为69.9纳摩尔/升，每周服用后为67.2纳摩尔/升，每月服用后为53.1纳摩尔/升，组间P<0.001）。血清PTH中位数水平下降了23%（p<0.001）。骨转换标志物未下降。补钙对血清PTH和骨转换无影响。
每日服用维生素D比每周服用更有效，每月服用效果最差。
