Pettinato C, Sarnelli A, Di Donna M, Civollani S, Nanni C, Montini G, Di Pierro D, Ferrari M, Marengo M, Bergamini C
Health Physics, A.O. S. Orsola-Malpighi, Bologna, Italy.
Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):72-9. doi: 10.1007/s00259-007-0587-y. Epub 2007 Sep 14.
The aim of this work was the evaluation of biodistribution and radiation dosimetry of (68)Ga-DOTANOC in patients affected by neuroendocrine tumors.
We enrolled nine patients (six male and three female) affected by different types of neuroendocrine tumors (NETs). Each patient underwent four whole body positron emission tomography (PET) scans, respectively, at 5, 20, 60, and 120 min after the intravenous injection of about 185 MBq of (68)Ga-DOTANOC. Blood and urine samples were taken at different time points post injection: respectively, at about 5, 18, 40, 60, and 120 min for blood and every 40-50 min from injection time up to 4 h for urine. The organs involved in the dosimetric evaluations were liver, heart, spleen, kidneys, lungs, pituitary gland, and urinary bladder. Dosimetric evaluations were done using the OLINDA/EXM 1.0 software.
A physiological uptake of (68)Ga-DOTANOC was seen in all patients in the pituitary gland, the spleen, the liver, and the urinary tract (kidneys and urinary bladder). Organs with the highest absorbed doses were kidneys (9.0E-02+/-3.2E-02mSv/MBq). The mean effective dose equivalent (EDE) was 2.5E-02+/-4.6E-03 mSv/MBq.
The excretion of the compound was principally via urine, giving dose to the kidney and the urinary bladder wall. As SSTR2 is the most frequently expressed somatostatin receptor and (68)Ga-DOTANOC has high affinity to it, this compound might play an important role in PET oncology in the future. The dosimetric evaluation carried out by our team demonstrated that (68)Ga-DOTANOC delivers a dose to organs comparable to, and even lower than, analogous diagnostic compounds.
本研究旨在评估（68）Ga-DOTANOC在神经内分泌肿瘤患者中的生物分布及辐射剂量学。
我们纳入了9例（6例男性和3例女性）患有不同类型神经内分泌肿瘤（NETs）的患者。每位患者在静脉注射约185 MBq的（68）Ga-DOTANOC后，分别在5、20、60和120分钟接受4次全身正电子发射断层扫描（PET）。在注射后的不同时间点采集血液和尿液样本：血液样本分别在约5、18、40、60和120分钟采集，尿液样本从注射时间起每40 - 50分钟采集一次，直至4小时。剂量学评估涉及的器官有肝脏、心脏、脾脏、肾脏、肺、垂体和膀胱。使用OLINDA/EXM 1.0软件进行剂量学评估。
所有患者的垂体、脾脏、肝脏及泌尿系统（肾脏和膀胱）均可见（68）Ga-DOTANOC的生理性摄取。吸收剂量最高的器官是肾脏（9.0E - 02±3.2E - 02 mSv/MBq）。平均有效剂量当量（EDE）为2.5E - 02±4.6E - 03 mSv/MBq。
该化合物主要通过尿液排泄，使肾脏和膀胱壁受到辐射剂量。由于SSTR2是最常表达的生长抑素受体，且（68）Ga-DOTANOC对其具有高亲和力，该化合物未来可能在PET肿瘤学中发挥重要作用。我们团队进行的剂量学评估表明，（68）Ga-DOTANOC对器官的辐射剂量与类似诊断化合物相当，甚至更低。
