Seiscento Márcia, Vargas Francisco S, Antonangelo Leila, Acencio Milena M P, Bombarda Sidney, Capelozzi Vera L, Teixeira Lisete R
Laboratory of Pleura, Pulmonary Division, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
Respirology. 2007 Sep;12(5):660-3. doi: 10.1111/j.1440-1843.2007.01135.x.
To clarify the influence of transforming growth factor beta-1 (TGF-beta(1)) in the development of pleural thickening in tuberculosis (TB), the levels of TGF-beta(1) in pleural fluid and in serum of patients with pleural TB and transudative effusions were determined.
TGF-beta(1) was quantified in 58 pleural fluid and serum samples of patients with TB (n = 50) or transudative effusions (n = 8). Pleural thickening evaluated by high-resolution CT was scored as 0 (<3 mm); 1 (>or=3 and <10 mm) or 2 (>or=10 mm).
The highest pleural fluid TGF-beta(1) levels before treatment for TB were observed in patients with a pleural thickness score of 2. Of the 14 patients with score 1, five regressed to 0, five progressed to 2, and four maintained 1. All 17 patients with score 2 maintained this evaluation. Patients who presented score 1 and progressed to 2 had higher TGF-beta(1) levels than those who maintained the same score or regressed (score 1 or 0). Patients with score 2 (before or after treatment) had higher TGF-beta(1) levels than those with score 0 or 1.
Pleural fluid and serum TGF-beta(1) levels were higher in patients with TB, with a correlation between pleural fluid TGF-beta(1) levels before treatment and the degree of pleural thickening. This finding suggests that TGF-beta(1) might be considered as a predictor of pleural thickening in pleural tuberculosis.
为阐明转化生长因子β1（TGF-β1）在结核性胸膜炎胸膜增厚发展过程中的作用，测定了结核性胸膜炎患者及漏出液患者胸水和血清中TGF-β1的水平。
对58例结核患者（n = 50）或漏出液患者（n = 8）的胸水和血清样本进行TGF-β1定量分析。通过高分辨率CT评估的胸膜增厚情况分为：0分（<3 mm）；1分（≥3且<10 mm）或2分（≥10 mm）。
胸膜厚度评分为2分的结核患者治疗前胸水TGF-β1水平最高。在14例评分为1分的患者中，5例降至0分，5例升至2分，4例维持在1分。所有17例评分为2分的患者维持该评分。评分为1分且升至2分的患者TGF-β1水平高于维持原评分或降至（评分为1分或0分）的患者。评分为2分（治疗前后）的患者TGF-β1水平高于评分为0分或1分的患者。
结核患者胸水和血清TGF-β1水平较高，治疗前胸水TGF-β1水平与胸膜增厚程度相关。这一发现提示TGF-β1可能是结核性胸膜炎胸膜增厚的一个预测指标。
