Suzuki Manabu, Hirano Satoshi, Ito Hideyuki, Matsubara Daisuke, Kubota Kazuo, Takeda Yuichiro, Sugiyama Haruhito, Kobayashi Nobuyuki, Kudo Koichiro
Department of Respiratory Medicine, International Medical Center of Japan Hospital, Tokyo, Japan.
Respirology. 2007 Sep;12(5):774-6. doi: 10.1111/j.1440-1843.2007.01139.x.
Low dose weekly administration of methotrexate has been thought to be effective for both rheumatoid arthritis (RA) and psoriasis. However, there is a possibility that methotrexate therapy may be oncogenic. This report presents a case of pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis. Physicians should be aware that Epstein-Barr virus-associated lymphoproliferative disorders that occur during treatment with methotrexate are not specific to patients with RA.
低剂量甲氨蝶呤每周给药一直被认为对类风湿性关节炎（RA）和银屑病均有效。然而，甲氨蝶呤治疗可能具有致癌性。本报告介绍了1例在长期使用甲氨蝶呤治疗银屑病期间发生肺淋巴瘤的病例。医生应意识到，在甲氨蝶呤治疗期间发生的与爱泼斯坦-巴尔病毒相关的淋巴增生性疾病并非RA患者所特有。
