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Noscapine may increase the effect of warfarin.那可丁可能会增强华法林的药效。
Br J Clin Pharmacol. 2008 Feb;65(2):277-8. doi: 10.1111/j.1365-2125.2007.03018.x. Epub 2007 Sep 13.
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Targeting GLI1 and BAX by nanonoscapine could impede prostate adenocarcinoma progression.纳诺斯卡品通过靶向 GLI1 和 BAX 抑制前列腺腺癌进展。
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Assessment of Dry Heating, Water Rinsing, and Baking on Concentrations of the Opium Alkaloid Noscapine in Poppy Seeds.干热、水洗和烘焙对罂粟籽中鸦片生物碱那可丁浓度的影响评估。
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Interaction of OTC drug noscapine and acenocoumarol and phenprocoumon.非处方药物那可丁与醋硝香豆素和苯丙香豆素的相互作用。
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The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.《那可丁编年史：阿片生物碱家族的药物史传记及其临床应用》
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Warfarin-associated bleeding events and concomitant use of potentially interacting medicines reported to the Norwegian spontaneous reporting system.华法林相关出血事件和同时使用可能相互作用的药物向挪威自发报告系统报告。
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Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction.纳布啡对 CYP3A4 和 CYP2C9 的时间依赖性抑制（TDI）可能解释了临床纳布啡-华法林相互作用。
Br J Clin Pharmacol. 2010 Feb;69(2):193-9. doi: 10.1111/j.1365-2125.2009.03572.x.

本文引用的文献

1
Association of warfarin dose with genes involved in its action and metabolism.华法林剂量与其作用和代谢相关基因的关联。
Hum Genet. 2007 Mar;121(1):23-34. doi: 10.1007/s00439-006-0260-8. Epub 2006 Oct 18.
2
Modulatory influence of noscapine on the ethanol-altered hepatic biotransformation system enzymes, glutathione content and lipid peroxidation in vivo in rats.那可丁对大鼠体内乙醇改变的肝脏生物转化系统酶、谷胱甘肽含量及脂质过氧化的调节作用。
Eur J Drug Metab Pharmacokinet. 2004 Jul-Sep;29(3):157-62. doi: 10.1007/BF03190592.
3
Application of data mining techniques in pharmacovigilance.数据挖掘技术在药物警戒中的应用。
Br J Clin Pharmacol. 2004 Feb;57(2):127-34. doi: 10.1046/j.1365-2125.2003.01968.x.
4
Alteration of drug biotransformation and elimination during infection and inflammation.感染和炎症期间药物生物转化及消除的改变。
Pharmacol Ther. 2001 Nov-Dec;92(2-3):147-63. doi: 10.1016/s0163-7258(01)00165-6.
5
Pharmacokinetics of oral noscapine.
Eur J Clin Pharmacol. 1990;39(3):275-9. doi: 10.1007/BF00315110.

Noscapine may increase the effect of warfarin.

作者信息

Ohlsson Staffan, Holm Lennart, Myrberg Olle, Sundström Anders, Yue Qun-Ying

出版信息

Br J Clin Pharmacol. 2008 Feb;65(2):277-8. doi: 10.1111/j.1365-2125.2007.03018.x. Epub 2007 Sep 13.

DOI:10.1111/j.1365-2125.2007.03018.x
PMID:17875192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2291222/
Abstract
摘要