Weller R E, Málaga C A, Buschbom R L, Baer J F, Ragan H A
Developmental Toxicology Section, Battelle, Pacific Northwest Laboratory, Richland, WA 99352.
J Med Primatol. 1991 Sep;20(7):365-9.
The excretion of urinary protein was evaluated in 62 owl monkeys using timed urine collections. The ratio of urine protein to urine creatinine concentrations (Up/c) was determined for each monkey. Linear regression analysis was used to calculate the correlation between that ratio and urine protein (mg/dl) and 24-hour urinary protein loss (mg/kg). The coefficient of determination for Up/c to urine protein and 24-hour urinary protein loss was significant (P less than or equal to 0.0001). Determination of the Up/c in a urine specimen was found to be an acceptable diagnostic technique for detection and quantitative estimation of proteinuria.
通过定时收集尿液，对62只夜猴的尿蛋白排泄情况进行了评估。测定了每只猴子尿蛋白与尿肌酐浓度的比值（Up/c）。采用线性回归分析来计算该比值与尿蛋白（mg/dl）和24小时尿蛋白丢失量（mg/kg）之间的相关性。Up/c与尿蛋白及24小时尿蛋白丢失量的决定系数具有显著性（P小于或等于0.0001）。结果发现，测定尿液标本中的Up/c是一种可接受的用于检测和定量评估蛋白尿的诊断技术。
