Grauer G F, Thomas C B, Eicker S W
Am J Vet Res. 1985 Oct;46(10):2116-9.
The correlation between 24-hour urine protein excretion and the protein-to-creatinine ratio (U-P/C) from random, voided urine specimens was assessed in 16 healthy Beagles (9 to 11 months old) and in 14 dogs with suspected renal proteinuria. Initially, a voided urine specimen was obtained from each dog, and the U-P/C was determined. An attempt was not made to standardize the time of collection of the voided urine. Subsequently, each dog was placed in a metabolism cage, and 24-hour urine specimens were collected for quantitative protein analysis. The Coomassie blue technique was used to measure urine protein. The correlation between the U-P/C and the 24-hour urine protein excretion (mg/kg/24 hr), evaluated by linear-regression analysis, was found to be significant (r = 0.975, P less than 0.01). These results substantiate previous findings and indicate that random, voided urine specimens may be used to compute the ratio and to accurately reflect 24-hour urinary protein loss in the dog.
在16只健康的比格犬（9至11个月大）和14只疑似肾性蛋白尿的犬中，评估了随机采集的晨尿标本中24小时尿蛋白排泄量与蛋白/肌酐比值（U-P/C）之间的相关性。最初，从每只犬获取一份晨尿标本，并测定U-P/C。未尝试对晨尿采集时间进行标准化。随后，将每只犬置于代谢笼中，收集24小时尿液标本进行蛋白质定量分析。采用考马斯亮蓝技术测定尿蛋白。通过线性回归分析评估，发现U-P/C与24小时尿蛋白排泄量（mg/kg/24小时）之间的相关性显著（r = 0.975，P < 0.01）。这些结果证实了先前的发现，并表明随机采集的晨尿标本可用于计算该比值，并准确反映犬的24小时尿蛋白丢失情况。
