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2
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Essential role for CD40 ligand interactions in T lymphocyte-mediated modulation of the murine immune response to pneumococcal capsular polysaccharides.CD40配体相互作用在T淋巴细胞介导的对肺炎球菌荚膜多糖的小鼠免疫反应调节中的重要作用。
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Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.边缘区巨噬细胞表达的特异性细胞间黏附分子3抓取非整合素相关分子1（SIGNR1）对于抵御肺部肺炎链球菌感染至关重要。
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SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages.在杜氏利什曼原虫诱导边缘区巨噬细胞缺失后，SIGNR1阴性的红髓巨噬细胞可预防急性链球菌败血症。
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本文引用的文献

1
PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES.以特定荚膜多糖免疫预防肺炎球菌肺炎。
J Exp Med. 1945 Nov 30;82(6):445-65.
2
Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.边缘区巨噬细胞表达的特异性细胞间黏附分子3抓取非整合素相关分子1（SIGNR1）对于抵御肺部肺炎链球菌感染至关重要。
Eur J Immunol. 2005 Oct;35(10):2962-9. doi: 10.1002/eji.200526216.
3
In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands.对分离出的肺炎球菌多糖的体内体液免疫反应取决于相关Toll样受体配体的存在。
J Immunol. 2005 Sep 1;175(5):3084-91. doi: 10.4049/jimmunol.175.5.3084.
4
Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells.前沿：针对肺炎球菌多糖产生抗体需要CD1分子和CD8+ T细胞。
J Immunol. 2005 Feb 15;174(4):1787-90. doi: 10.4049/jimmunol.174.4.1787.
5
SIGN-R1 contributes to protection against lethal pneumococcal infection in mice.SIGN - R1有助于小鼠抵御致死性肺炎球菌感染。
J Exp Med. 2004 Dec 6;200(11):1383-93. doi: 10.1084/jem.20040795.
6
Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins.小鼠DC-SIGN、SIGNR1、SIGNR3和Langerin这几种C型凝集素的功能比较。
Int Immunol. 2004 Jun;16(6):819-29. doi: 10.1093/intimm/dxh084. Epub 2004 Apr 19.
7
The human antibody response to pneumococcal capsular polysaccharides is dependent on the CD40-CD40 ligand interaction.人类对肺炎球菌荚膜多糖的抗体反应依赖于CD40-CD40配体相互作用。
Eur J Immunol. 2004 Mar;34(3):850-858. doi: 10.1002/eji.200324381.
8
The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.SIGNR1和β-葡聚糖受体（dectin-1）在特定巨噬细胞对酵母的非调理素依赖性识别中的作用。
J Immunol. 2004 Jan 15;172(2):1157-62. doi: 10.4049/jimmunol.172.2.1157.
9
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.C型凝集素SIGN-R1介导小鼠脾脏边缘区肺炎链球菌荚膜多糖的摄取。
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):215-20. doi: 10.1073/pnas.0307124101. Epub 2003 Dec 23.
10
T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens.抗体对“2型非T淋巴细胞依赖性”抗原反应的T淋巴细胞依赖性
Immunology. 2004 Jan;111(1):1-7. doi: 10.1111/j.1365-2567.2004.01775.x.

特异性细胞内黏附分子结合非整合素R1不参与小鼠对肺炎球菌多糖的抗体反应。

Specific intracellular adhesion molecule-grabbing nonintegrin R1 is not involved in the murine antibody response to pneumococcal polysaccharides.

作者信息

Moens Leen, Jeurissen Axel, Wuyts Greet, Fallon Padraic G, Louis Boon, Ceuppens Jan L, Bossuyt Xavier

机构信息

Department of Medical Diagnostic Sciences, Laboratory of Experimental Laboratory Medicine, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium.

出版信息

Infect Immun. 2007 Dec;75(12):5748-52. doi: 10.1128/IAI.00574-07. Epub 2007 Sep 17.

DOI:10.1128/IAI.00574-07
PMID:17875633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2168319/
Abstract

Streptococcus pneumoniae is a microorganism that frequently causes serious infections in children, the elderly, and immunocompromised patients. We studied whether the specific intracellular adhesion molecule-grabbing nonintegrin R1 (Sign-R1) receptor, involved in the uptake of capsular polysaccharides (caps-PS) by antigen-presenting cells, is necessary for the antibody response to pneumococcal caps-PS and phosphorylcholine (PC). The antibody response to caps-PS and PC was evaluated after vaccination with soluble caps-PS (Pneumovax) and after vaccination with heat-killed S. pneumoniae. The role of Sign-R1 was investigated by using Sign-R1 knockout mice and anti-Sign-R1 monoclonal antibodies. The immunoglobulin M (IgM) and IgG antibody response to PC and caps-PS (serotypes 3 and 14) was not affected by anti-Sign-R1 monoclonal antibodies. The IgM antibody response in Sign-R1 knockout mice was comparable to the antibody response in wild-type mice. The IgG antibody response to serotype 3, but not to serotype 14, tended to be lower in Sign-R1 knockout mice compared to wild-type mice. In conclusion, we found that Sign-R1 is not involved in the IgM antibody production to PC and caps-PS serotype 3 or 14 and the IgG immune response to PC and caps-PS serotype 14. There is no direct relation between capture and uptake of caps-PS serotype 14 by Sign-R1 and the initiation of the anti-caps-PS antibody production in mice.

摘要

肺炎链球菌是一种经常在儿童、老年人和免疫功能低下患者中引起严重感染的微生物。我们研究了参与抗原呈递细胞摄取荚膜多糖（caps-PS）的特异性细胞内粘附分子捕获非整合素R1（Sign-R1）受体，对于肺炎球菌caps-PS和磷酸胆碱（PC）的抗体反应是否必要。在用可溶性caps-PS（肺炎球菌多糖疫苗）接种后以及在用热灭活的肺炎链球菌接种后，评估了对caps-PS和PC的抗体反应。通过使用Sign-R1基因敲除小鼠和抗Sign-R1单克隆抗体研究了Sign-R1的作用。抗Sign-R1单克隆抗体未影响对PC和caps-PS（血清型3和14）的免疫球蛋白M（IgM）和IgG抗体反应。Sign-R1基因敲除小鼠中的IgM抗体反应与野生型小鼠中的抗体反应相当。与野生型小鼠相比，Sign-R1基因敲除小鼠中对血清型3而非血清型14的IgG抗体反应往往较低。总之，我们发现Sign-R1不参与对PC和血清型3或14的caps-PS的IgM抗体产生以及对PC和血清型14的caps-PS的IgG免疫反应。Sign-R1对血清型14的caps-PS的捕获和摄取与小鼠中抗caps-PS抗体产生的启动之间没有直接关系。